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KMID : 0365819770170020203
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Journal of Pusan Medical College
1977 Volume.17 No. 2 p.203 ~ p.210
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A Clinical Study on Trial of Oral Administraion of 5-Fluorouracil in Cancer of the Gastrointestinal Tract
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Abstract
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At present, surgery represents the most successful means of dealing with cancer as long as it remains localized to the primary site and regional lymphnodes, but can not be considered curative once the disease has metstasized beyond the local region, although this method may be useful as palliative treatment.
Chemotherapy and immunotherapy unlike surgery represent systemic form of treatment effective against tumor cells already metastatic to distant sites and residual local or distant foci of malignant cells following removal of the local tumor mass and thus may be the most attractive and logical possibilities for improving survival of the cancer patient.
5-fluorouracil (5-FU) and its nucleoside derivatives were the first drugs to prove capable of inducing regression of gastrointestinal adenocarcinoma, and today, almost two decades after their introduction to clinical trial, they remain the most active single agents for this class of neoplasm.
Postoperative oral administration of 5-FU and intramuscular injection of Tubercin 3 were tried to 22 cases of gastrointestinal tract from Jan. 1975 to Sept. 1977 at Dept. of surgery, College of Medicine, Busan National University.
5-FU was orally administered at dose of 15 mg/kg daily for one month and followed by monthly interval administration for two times at same dose level. Tubercin 3 was intramuscularly given at dose of 1oc for 20 days.
The observed diseases of gastrointestinal cancer with these therapeutic modality were stomach in 11 cases, colon and rectum in 7 cases, liver in 2 cases, extrahepatic biliary system in 1 case and pancreas in 1 case.
During the same period, 9 cases of stomach cancer and 7 cases of colon and rectum cancer were followup studied, which were managed by surgery only.
When with these patient were compared to patients treated by surgery alone, there was somewhat improvement in recurrent subjective symptoms and survival.
The side effect of 5-FU was minimal and readily reversible, and gastrointestinal toxicity was much frequent comparing with hematologic toxicity.
This report will have to be continued for further study and follow-up.
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KEYWORD
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